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The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines.

Authors
  • Rosso, Marisa1
  • Robles-Frías, María Jose
  • Coveñas, Rafael
  • Salinas-Martín, Manuel Vicente
  • Muñoz, Miguel
  • 1 Virgen del Rocío University Children's Hospital, Sevilla, Spain.
Type
Published Article
Journal
Tumor Biology
Publisher
SAGE Publications
Publication Date
2008
Volume
29
Issue
4
Pages
245–254
Identifiers
DOI: 10.1159/000152942
PMID: 18781096
Source
Medline
License
Unknown

Abstract

We demonstrated that NK-1 receptors were expressed in 23132/37 and SW-403 cell lines and in human primary gastric and colon adenocarcinomas, that SP is a mitogen and that the antitumor action of L-733,060 on both human cell lines occurs through the NK-1 receptor. Data also indicate that the cell death observed is produced by apoptosis. These data suggest that the NK-1 receptor is a new and promising target in the treatment of human gastrointestinal adenocarcinomas.

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