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Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe

Authors
  • Driesschaert, Benoit1, 2
  • Bobko, Andrey A.1, 2
  • Khramtsov, Valery V.1, 2
  • Zweier, Jay L.3
  • 1 West Virginia University, In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, Morgantown, WV, 26506, USA , Morgantown (United States)
  • 2 West Virginia University School of Medicine, Department of Biochemistry, 1 Medical Center Drive, Morgantown, WV, 26506, USA , Morgantown (United States)
  • 3 The Ohio State University/Wexner Medical Center, Davis Heart and Lung Research Institute, 460 West 12th Avenue, BRT 0390, Columbus, OH, 43210, USA , Columbus (United States)
Type
Published Article
Journal
Cell Biochemistry and Biophysics
Publisher
Springer-Verlag
Publication Date
May 20, 2016
Volume
75
Issue
2
Pages
241–246
Identifiers
DOI: 10.1007/s12013-016-0732-y
Source
Springer Nature
Keywords
License
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Abstract

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1 s−1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

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