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Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe.

Authors
  • Driesschaert, Benoit1, 2
  • Bobko, Andrey A3, 4
  • Khramtsov, Valery V5, 6
  • Zweier, Jay L7
  • 1 In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA. [email protected]
  • 2 Department of Biochemistry, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9142, Morgantown, WV, 26506, USA. [email protected]
  • 3 In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA.
  • 4 Department of Biochemistry, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9142, Morgantown, WV, 26506, USA.
  • 5 In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA. [email protected]
  • 6 Department of Biochemistry, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9142, Morgantown, WV, 26506, USA. [email protected]
  • 7 Davis Heart and Lung Research Institute, The Ohio State University/Wexner Medical Center, 460 West 12th Avenue, BRT 0390, Columbus, OH, 43210, USA. [email protected]
Type
Published Article
Journal
Cell Biochemistry and Biophysics
Publisher
Springer-Verlag
Publication Date
June 2017
Volume
75
Issue
2
Pages
241–246
Identifiers
DOI: 10.1007/s12013-016-0732-y
PMID: 27206803
Source
Medline
Keywords
License
Unknown

Abstract

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M-1 s-1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

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