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The nitrofurans as sperm-immobilizing agents, their tissue toxicity, and their clinical application in vasectomy.

Authors
Type
Published Article
Journal
Fertility and Sterility
0015-0282
Publisher
Elsevier
Publication Date
Volume
26
Issue
6
Pages
485–491
Identifiers
PMID: 1132530
Source
Medline

Abstract

Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicity in the guinea pig. Clinically, we found intraoperative vas irrigation with both of these nontoxic drugs to be of value in attaining azoospermia immediately postvasectomy. Therefore, they appear to be useful supplements to vasectomy.

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