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Nitrite promotes lymphoma incidence in rats.

Authors
  • Newberne, P M
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jun 08, 1979
Volume
204
Issue
4397
Pages
1079–1081
Identifiers
PMID: 451551
Source
Medline
License
Unknown

Abstract

Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte.

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