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Nitric oxide synthase is concentrated at the skeletal muscle endplate.

Authors
  • Kusner, L L
  • Kaminski, H J
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Aug 19, 1996
Volume
730
Issue
1-2
Pages
238–242
Identifiers
PMID: 8883910
Source
Medline
License
Unknown

Abstract

NO performs a wide array of cell signaling functions. Neuronal NO synthase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide phosphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscle indicating the localization of the enzyme to the postsynaptic surface. The concentration of nNOS at the muscle endplate suggests NO could serve as a messenger pre- and postsynapticly.

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