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Nitric Oxide Reverses the Position of the Heart during Embryonic Development

Authors
  • Siamwala, Jamila H
  • Kumar, Pavitra
  • Veeriah, Vimal
  • Muley, Ajit
  • Rajendran, Saranya
  • Konikkat, Salini
  • Majumder, Syamantak
  • Mani, Krishna Priya
  • Chatterjee, Suvro
Publication Date
Mar 07, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

8 resulted in embryos with situs inversus in 28 out of 100 embryos tested. Embryos treated with NO inhibitor cPTIO did not have situs inversus, however 10 embryos treated with L-arginine showed a situs inversus phenotype. N-acetyl cysteine addition in the presence of NO failed to rescue situs inversus phenotype. The heart beat is normal (120 beats/min) although the vascular bed pattern is altered. Migration of CPCs in DEAN treated embryos is reduced by 60% compared to vehicle. BMP4 protein expression increases on the left side of the embryo compared to vehicle control. The data suggests that the NO levels in the yolk are important in turning of the heart during embryonic development. High levels of NO may lead to situs inversus condition in avian embryo by impairing cardiac progenitor cell migration through the NO-BMP4-cGMP axis.

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