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Nitric oxide and prostacyclin modulate the alterations in cardiac action potential duration mediated by platelets during ischaemia.

Authors
Type
Published Article
Journal
Cardiovascular research
Publication Date
Volume
30
Issue
5
Pages
788–798
Identifiers
PMID: 8595628
Source
Medline
License
Unknown

Abstract

Inhibition of NO and PGI2 synthesis exacerbates the reduction in cardiac action potential duration associated with platelet activation during ischaemia, while provision of exogenous NO and PGI2 attenuates the reduction in cardiac action potential duration. Provision of exogenous NO and PGI2 (as iloprost) was associated with inhibition of platelet reactivity.

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