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Nitric oxide: pros and cons in tumor progression.

Authors
  • 1
  • 1 Department of Biotechnology, Karunya University, Coimbatore 641114, Tamil Nadu, India. , (India)
Type
Published Article
Journal
Immunopharmacology and Immunotoxicology
1532-2513
Publisher
Informa UK (Taylor & Francis)
Publication Date
Volume
32
Issue
3
Pages
387–392
Identifiers
DOI: 10.3109/08923970903440192
PMID: 20095804
Source
Medline
License
Unknown

Abstract

Nitric oxide (NO), synthesized by NO synthase, is a mediator involved in different processes varying from neurotransmission, to affecting the vasculature. The role of NO in tumor development is multifaceted and depends on a variety of conditions that exist with in the cell. This review will discuss the pros and cons of NO in tumor progression and provide an overview of their significant part in metabolism, angiogenesis and their role in the activation of macrophages as well as tumor-associated macrophages. The role of natural products in the regulation of NO will also be discussed.

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