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Nissen fundoplication has a vagolytic effect on the lower esophageal sphincter.

Authors
Type
Published Article
Journal
Surgical Endoscopy
1432-2218
Publisher
Springer-Verlag
Publication Date
Volume
17
Issue
8
Pages
1206–1211
Identifiers
PMID: 12739125
Source
Medline

Abstract

Nissen fundoplication may prevent GERD in those without a hiatal hernia or incompetent LES by disrupting the efferent vagal fibers to the LES. Such fibers mediate TLESR which are responsible for GERD in these patients.

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