Affordable Access

Nifedipine induced autophagy through Beclin1 and mTOR pathway in endometrial carcinoma cells.

Authors
  • Bao, Xiao-Xia
  • Xie, Bu-Shan
  • Li, Qi
  • Li, Xiao-Ping
  • Wei, Li-Hui
  • Wang, Jian-Liu
Type
Published Article
Journal
Chinese medical journal
Publication Date
Sep 01, 2012
Volume
125
Issue
17
Pages
3120–3126
Identifiers
PMID: 22932192
Source
Medline
License
Unknown

Abstract

Proliferation and migration in vitro of endometrial carcinoma Hec-1A cells are significantly suppressed by nifedipine. The nifedipine leads autophagy to oppose Hec-1A cells apoptosis. Autophagy inhibition by 3-MA leads down-regulation of Cav1.3 and enhances nifedipine-induced cell death. The nifedipine-induced autophagy is linked to Beclin1 and mTOR pathways.

Report this publication

Statistics

Seen <100 times