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Nidation in weanling rats treated with PMS and gonadal steroids.

Authors
Type
Published Article
Journal
Fertility and Sterility
0015-0282
Publisher
Elsevier
Publication Date
Volume
20
Issue
4
Pages
667–673
Identifiers
PMID: 5795046
Source
Medline
Keywords
  • Animals, Laboratory
  • Biology
  • Clinical Research
  • Contraception
  • Contraceptive Agents
  • Contraceptive Agents, Female
  • Contraceptive Agents, Progestin
  • Contraceptive Mode Of Action
  • Endocrine System
  • Estradiol--Administraction And Dosage
  • Estradiol--Side Effects
  • Estrogens
  • Family Planning
  • Gonadotropins
  • Gonadotropins, Chorionic--Administraction And Dosage
  • Gonadotropins, Chorionic--Side Effects
  • Hormones
  • Implantation Suppression
  • Medroxyprogesterone Acetate
  • Physiology
  • Progestational Hormones
  • Progesterone--Administraction And Dosage
  • Progesterone--Side Effects
  • Research Methodology

Abstract

Implantation was studied in 22-day-old female rats to determine the precise amounts of ovarian hormones needed for implantation of blastocysts. 3 mg of medroxyprogesterone was given to increase the percentage of animals with delayed implantation. .1 mcg estradiol-17beta given on Day 4 produced about 50% blastocyst implantation. 105 or .025 mcg estradiol-17beta given on Day 5 of pregnancy induced nidation in 8 out of 17 and 6 out of 8 rats, respectively. There was no significant difference between control and treated groups with regard to the number of animals with delayed blastocyst implantation and the average number of blastocysts recovered. Daily injection of progesterone helped to cause nidation. High doses of progesterone provide the ratio of progesterone to estrogen needed for implantation and also support the idea that nidation may be triggered by the rise in progesterone level in the presence of a constant amount of estrogen.

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