Affordable Access

Nicotine increases stress-induced serotonin release by stimulating nicotinic acetylcholine receptor in rat striatum.

Authors
  • Takahashi, H
  • Takada, Y
  • Nagai, N
  • Urano, T
  • Takada, A
Type
Published Article
Journal
Synapse (New York, N.Y.)
Publication Date
Mar 01, 1998
Volume
28
Issue
3
Pages
212–219
Identifiers
PMID: 9488506
Source
Medline
License
Unknown

Abstract

We used a microdialysis technique to analyze the effects of footshock stress on the release of serotonin (5-hydroxytryptamine: 5-HT) in the striatum or prefrontal cortex (PFC) in rats that were pretreated with nicotine. Neither nicotine administration alone nor stress application alone changed 5-HT release. During stress application, however, both chronic nicotine administration and local infusion of nicotine to the striatum significantly increased 5-HT release in the striatum, though not in the PFC. These increases in 5-HT release were eradicated by a local infusion of mecamylamine. Release of 5-HT increased in the striatum during stress application when nicotine was injected to the striatum, while nicotinic injection to the dorsal raphe nucleus did not increase 5-HT release in the striatum. The present study demonstrates that nicotine induced a release of 5-HT upon stress application by stimulating presynaptic nicotinic receptors in the striatum.

Report this publication

Statistics

Seen <100 times