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Nicotinamide and other inhibitors of ADP-ribosylation block deoxyglucose uptake in cultured cells.

Authors
  • Grunfeld, C
  • Shigenaga, J K
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Sep 17, 1984
Volume
123
Issue
2
Pages
785–791
Identifiers
PMID: 6237649
Source
Medline
License
Unknown

Abstract

Nicotinamide was shown to inhibit deoxyglucose uptake in three diverse differentiated cell lines. In 3T3-L1 fat cells, nicotinamide equally inhibited basal and insulin stimulated deoxyglucose uptake. Inhibition by nicotinamide was non-competitive. A variety of inhibitors of ADP-ribosylation blocked deoxyglucose uptake while some analogs with no activity against ADP-ribose synthetase also had little effect on deoxyglucose uptake. These findings should be taken into account when inhibitors of ADP-ribosylation are used with intact cells.

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