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Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance

Authors
  • Akar, Serra1
  • Harmankaya, İsmail2
  • Uğraş, Serdar2
  • Çintesun, Ersin3
  • Çelik, Çetin1
  • 1 Selcuk University Medical School, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Konya, 60615, Turkey , Konya (Turkey)
  • 2 Selcuk University Medical School, Department of Pathology, Konya, Turkey , Konya (Turkey)
  • 3 Selcuk University Medical School, Department of Obstetrics and Gynecology, Konya, Turkey , Konya (Turkey)
Type
Published Article
Journal
Indian Journal of Gynecologic Oncology
Publisher
Springer India
Publication Date
Jul 24, 2019
Volume
17
Issue
3
Identifiers
DOI: 10.1007/s40944-019-0309-y
Source
Springer Nature
Keywords
License
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Abstract

IntroductionNicotinamide N-methyltransferase (NNMT) is a metabolic enzyme increasingly implicated in tumor progression and resistance to treatment. It is overexpressed in human cancers including glioblastoma, gastric, pancreatic, lung and colorectal cancers. The role of NNMT in cervical adenocarcinoma has not been studied thus far. We aimed to evaluate expression of NNMT in cervical adenocarcinoma and investigate its prognostic significance.MethodsNNMT expression was assayed in 18 cases of cervical adenocarcinoma and 19 cases of benign cervical tissue. NNMT immunoreactivity was scored by multiplying staining intensity with percentage of immunoreactive cells.ResultsThe expression of NNMT was significantly higher in cervical adenocarcinoma than in benign tissue (p = 0.024). NNMT expression was significantly higher in patients with locally advanced than early cervical cancer (p = 0.031). NNMT expression was higher in patients with tumor size greater than 4 cm and in those with poorly differentiated tumors compared to patients with tumors of 4 cm or less and well-moderate differentiation, respectively (p = 0.044, p = 0.014).ConclusionAlthough on a preliminary level, this is the first study to detect an overexpression of NNMT in cervical adenocarcinoma and an increased expression associated with advanced stage, increased tumor size and poor differentiation. NNMT has been shown to carry prognostic and therapeutic importance in a variety of cancers, and it can be a potential treatment target in cervical adenocarcinomas.

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