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Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumors.

Authors
  • Kelleher, D K
  • Vaupel, P W
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Apr 30, 1993
Volume
26
Issue
1
Pages
95–102
Identifiers
PMID: 8482636
Source
Medline
License
Unknown

Abstract

These findings suggest that nicotinamide preferentially improves tumor microcirculatory function and effectuates a decrease in the arterial blood pressure/laser Doppler flux ratio within tumor tissue, effects which reach their maximum approximately 60 min following nicotinamide administration.

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