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NHC-catalyzed hydroacylation of styrenes.

Authors
  • Schedler, Michael
  • Wang, Duo-Sheng
  • Glorius, Frank
Type
Published Article
Journal
Angewandte Chemie International Edition in English
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 25, 2013
Volume
52
Issue
9
Pages
2585–2589
Identifiers
DOI: 10.1002/anie.201209291
PMID: 23355453
Source
Medline
License
Unknown

Abstract

New hydroacylation catalysts: Highly electron-rich N-heterocyclic carbenes (NHCs) facilitate the intermolecular hydroacylation of unstrained olefins. This unprecedented organocatalytic coupling joins simple and abundant aldehydes and styrenes to yield valuable ketone products. EWG=electron-withdrawing group, EDG=electron-donating group.

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