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NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels.

Authors
  • Lichvárová, Lucia
  • Jašková, Katarína
  • Lacinová, L'ubica
Type
Published Article
Journal
General physiology and biophysics
Publication Date
Dec 01, 2012
Volume
31
Issue
4
Pages
473–478
Identifiers
DOI: 10.4149/gpb_2012_054
PMID: 23255675
Source
Medline
License
Unknown

Abstract

Neuronal growth factor (NGF) induces neurodifferentiation of PC12 cells into cholinergic neurons-like cells. It was shown that intracellular Ca2+ ions participate in regulation of the differentiation of PC12 cells. We tested whether L-type calcium channels contribute to Ca2+ entry which supports neurite outgrowth accompanying NGF-activated differentiation process. Development of morphological changes did correlate with increase of functional expression of L-type calcium channels. However, inhibition of L-type calcium channels by 1 μM of isradipine did not affect significantly an NGF-activated neurite outgrowth.

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