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NFAT proteins: key regulators of T-cell development and function.

Authors
Type
Published Article
Journal
Nat Rev Immunol
1474-1733
Publisher
Nature Publishing Group
Publication Date
Volume
5
Issue
6
Pages
472–484
Identifiers
PMID: 15928679
Source
Medline
License
Unknown

Abstract

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance. The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.

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