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NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond.

Authors
  • Capece, Daria1
  • Verzella, Daniela2
  • Di Francesco, Barbara3
  • Alesse, Edoardo4
  • Franzoso, Guido5
  • Zazzeroni, Francesca6
  • 1 Centre for Cell Signalling and Inflammation, Department of Medicine, Imperial College London, W12 0NN London, UK. Electronic address: [email protected]
  • 2 Centre for Cell Signalling and Inflammation, Department of Medicine, Imperial College London, W12 0NN London, UK. Electronic address: [email protected]
  • 3 Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100, L'Aquila, Italy. Electronic address: [email protected] , (France)
  • 4 Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100, L'Aquila, Italy. Electronic address: [email protected] , (Italy)
  • 5 Centre for Cell Signalling and Inflammation, Department of Medicine, Imperial College London, W12 0NN London, UK. Electronic address: [email protected]
  • 6 Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100, L'Aquila, Italy. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Seminars in Cell and Developmental Biology
Publisher
Elsevier
Publication Date
Feb 01, 2020
Volume
98
Pages
118–128
Identifiers
DOI: 10.1016/j.semcdb.2019.05.021
PMID: 31132468
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

NF-κB plays a pivotal role in oncogenesis. This transcription factor is best known for promoting cancer cell survival and tumour-driving inflammation. However, several lines of evidence support a crucial role for NF-κB in governing energy homeostasis and mediating cancer metabolic reprogramming. Mitochondria are central players in many metabolic processes altered in cancer. Beyond their bioenergetic activity, several facets of mitochondria biology, including mitochondrial dynamics and oxidative stress, promote and sustain malignant transformation. Recent reports revealed an intimate connection between NF-κB pathway and the oncogenic mitochondrial functions. NF-κB can impact mitochondrial respiration and mitochondrial dynamics, and, reciprocally, mitochondria can sense stress signals and convert them into cell biological responses leading to NF-κB activation. In this review we discuss their emerging reciprocal regulation and the significance of this interplay for anticancer therapy. Copyright © 2019 Elsevier Ltd. All rights reserved.

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