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NeXO Web: the NeXO ontology database and visualization platform.

Authors
Type
Published Article
Journal
Nucleic Acids Research
Publisher
Oxford University Press
Volume
42
Issue
Database issue
Pages
1269–1274
Identifiers
DOI: 10.1093/nar/gkt1192
Source
Ideker Lab
License
Unknown

Abstract

The Network-extracted Ontology (NeXO) is a gene ontology inferred directly from large-scale molecular networks. While most ontologies are constructed through manual expert curation, NeXO uses a principled computational approach which integrates evidence from hundreds of thousands of individual gene and protein interactions to construct a global hierarchy of cellular components and processes. Here, we describe the development of the NeXO Web platform (http://www.nexontology.org)-an online database and graphical user interface for visualizing, browsing and performing term enrichment analysis using NeXO and the gene ontology. The platform applies state-of-the-art web technology and visualization techniques to provide an intuitive framework for investigating biological machinery captured by both data-driven and manually curated ontologies.

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