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The newer fluoroquinolones.

Authors
  • O'Donnell, Judith A
  • Gelone, Steven P
Type
Published Article
Journal
Infectious disease clinics of North America
Publication Date
Sep 01, 2004
Volume
18
Issue
3
Identifiers
PMID: 15308282
Source
Medline
License
Unknown

Abstract

This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin. Efficacy of the newer fluoroquinolones when compared with antimicrobial agents in other classes is also presented in detail. Appropriate use of the newer fluoroquinolones is addressed, including their ever expanding role in the treatment of both upper and lower respiratory tract infections and skin and soft tissue infection. Available data on the use of the newer fluoroquinolones in the management of genitourinary tract infections, gastrointestinal infections, and osteomyelitis are also discussed.

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