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Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farms.

Authors
  • Snoeck, Chantal J
  • Ducatez, Mariette F
  • Owoade, Ademola A
  • Faleke, Olufemi O
  • Alkali, Bello R
  • Tahita, Marc C
  • Tarnagda, Zekiba
  • Ouedraogo, Jean-Bosco
  • Maikano, Issoufou
  • Mbah, Patrick Okwen
  • Kremer, Jacques R
  • Muller, Claude P
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2009
Volume
154
Issue
1
Pages
47–54
Identifiers
DOI: 10.1007/s00705-008-0269-5
PMID: 19052688
Source
Medline
License
Unknown

Abstract

Forty-four Newcastle disease virus (NDV) strains, obtained between 2002 and 2007 from different poultry species in Nigeria, Niger, Burkina Faso and Cameroon, were phylogenetically analysed based on partial F sequences. Lineage 2 viruses were genetically identical or similar to the locally used LaSota vaccine strain and were mostly detected in commercial farms. Lineage 1, 3 and 4 strains were only sporadically found, and their origin was less clear. Twenty-one strains from backyard farms and live bird markets formed three new clusters within lineage 5, tentatively named 5f, 5g and 5h. All of these strains were predicted to be virulent based on their F protein cleavage site sequence. Minimal genetic distances between new and previously established sublineages ranged from 9.4 to 15.9%, and minimal distances between the new sublineages were 11.5 to 17.3%. Their high genetic diversity and their presence in three different Sub-Saharan countries suggest that these new sublineages represent the NDV variants indigenous to West Africa.

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