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New trichothecenes isolated from Holarrhena floribunda.

Authors
  • Loukaci, A
  • Kayser, O
  • Bindseil, K
  • Siems, K
  • Frevert, J
  • Abreu, P M
Type
Published Article
Journal
Journal of natural products
Publication Date
Jan 01, 2000
Volume
63
Issue
1
Pages
52–56
Identifiers
PMID: 10650079
Source
Medline
License
Unknown

Abstract

Bioassay-guided fractionation of an extract of Holarrhena floribunda stem, has led to the isolation of the new trichothecenes, 8-dihydrotrichothecinol A (1), loukacinol A (2), and loukacinol B (3), and the known compounds, trichothecolone (4), trichothecin (5), trichothecinol A (6), rosenonolactone (7), 6beta-hydroxyrosenonolactone (8), and rosololactone (9). The structures were determined by spectral and chemical methods, and absolute configurations were established by a modified Horeau's method using HPLC. Compounds 1 and 6 exhibited significant cytotoxicity against several human tumor cell lines, whereas compound 8 showed moderate and weak antileishmanial activity toward extracellular and intracellular Leishmania donovani, respectively.

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