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A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells.

Authors
  • Jiang, Guoyu1
  • Zhu, Wenping
  • Chen, Qingqing
  • Shi, Aiping
  • Wu, Yongquan
  • Zhang, Guanxin
  • Li, Xun
  • Li, Yongdong
  • Fan, Xiaolin
  • Wang, Jianguo
  • 1 Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, P. R. China. [email protected] , (China)
Type
Published Article
Journal
The Analyst
Publisher
The Royal Society of Chemistry
Publication Date
Nov 20, 2017
Volume
142
Issue
23
Pages
4388–4392
Identifiers
DOI: 10.1039/c7an01336a
PMID: 29116261
Source
Medline
License
Unknown

Abstract

An AIE based tetraphenylethylene derivative (TPPTPE) was synthesized for light-up sensing of ATP in aqueous solution. The measuring range for ATP can be tuned by varying the concentration of the TPPTPE. A one-step straightforward quantitative analysis of the ATP level in cell lysates can be realized using the TPPTPE. Moreover, the TPPTPE can be used for monitoring apyrase activity in aqueous solution and detecting ATP both in living cancer cell lines and in living normal cell lines.

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