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New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.

Authors
  • Ojima, I
  • Bounaud, P Y
  • Takeuchi, C
  • Pera, P
  • Bernacki, R J
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
189–194
Identifiers
PMID: 9871652
Source
Medline
License
Unknown

Abstract

New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

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