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New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes.

Authors
  • Dalton, Catherine M
  • Brex, Peter A
  • Miszkiel, Katherine A
  • Fernando, Kryshani
  • MacManus, David G
  • Plant, Gordon T
  • Thompson, Alan J
  • Miller, David H
Type
Published Article
Journal
Annals of neurology
Publication Date
May 01, 2003
Volume
53
Issue
5
Pages
673–676
Identifiers
PMID: 12731004
Source
Medline
License
Unknown

Abstract

In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium-enhancing lesions for dissemination in time at a 3-month follow-up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients.

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