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A New Spray Device to Deliver Topical Ocular Medication: Penetration of Fluorescein to the Anterior Segment.

Authors
  • van Rooij, Jeroen1
  • Wubbels, René J2
  • de Kruijf, Wilbur P J3
  • 1 1 The Rotterdam Eye Hospital , Rotterdam, the Netherlands . , (Netherlands)
  • 2 2 Rotterdam Ophthalmic Institute , Rotterdam, the Netherlands . , (Netherlands)
  • 3 3 Medspray BV , Enschede, the Netherlands . , (Netherlands)
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Nov 01, 2015
Volume
31
Issue
9
Pages
531–535
Identifiers
DOI: 10.1089/jop.2015.0022
PMID: 26062091
Source
Medline
License
Unknown

Abstract

It was demonstrated that fluorescein applied to the ocular surface with the spray device enters the AC. The total amount of fluorescein molecules reaching the ocular surface by the 2 methods of administration, however, is not equivalent. Therefore, no definitive conclusions on relative bioavailability can be drawn from this experiment.

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