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New silibinin glyco-conjugates: synthesis and evaluation of antioxidant properties.

Authors
  • Zarrelli, Armando
  • Romanucci, Valeria
  • Tuccillo, Concetta
  • Federico, Alessandro
  • Loguercio, Carmela
  • Gravante, Raffaele
  • Di Fabio, Giovanni
Type
Published Article
Journal
Bioorganic & medicinal chemistry letters
Publication Date
Nov 15, 2014
Volume
24
Issue
22
Pages
5147–5149
Identifiers
DOI: 10.1016/j.bmcl.2014.10.023
PMID: 25442301
Source
Medline
Keywords
License
Unknown

Abstract

New silibinin glyco-conjugates have been synthesized by efficient method and in short time. Exploiting our solution phase strategy, several structurally diverse silibinin glyco-conjugates (gluco, manno, galacto, and lacto-) were successfully realized in very good yields and in short time. In preliminary study to evaluate their antioxidant and neuroprotective activities new derivatives were subjected to DPPH free radical scavenging assay and the Xanthine oxidase (XO) inhibition models assay. Irrespective of the sugar moiety examined, new glyco-conjugates are more than 50 times water-soluble of silibinin. In the other hand they exhibit a radical scavenging activities slightly higher than to silibinin and XO inhibition at least as silibinin.

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