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New reductant-free synthesis of gold nanoparticles-doped chitosan-based semi-IPN nanogel: A robust nanoreactor for exclusively sensitive 5-fluorouracil sensor.

Authors
  • Vishnu S K, Deepak1
  • Ranganathan, Palraj1
  • Rwei, Syang-Peng2
  • Pattamaprom, Cattaleeya3
  • Kavitha, Thavuduraj4
  • Sarojini, Perumal4
  • 1 Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Research and Development Center for Smart Technology, Taipei 10608, Taiwan, ROC. , (Taiwan)
  • 2 Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Research and Development Center for Smart Technology, Taipei 10608, Taiwan, ROC. Electronic address: [email protected] , (Taiwan)
  • 3 Department of Chemical Engineering, Faculty Engineering, Thammasat University, Thailand. , (Thailand)
  • 4 Department of Chemistry, Sri S.Ramasamy Naidu Memorial College, Sattur, Virudhunagar 626 203, Tamilnadu, India. , (India)
Type
Published Article
Journal
International journal of biological macromolecules
Publication Date
Apr 01, 2020
Volume
148
Pages
79–88
Identifiers
DOI: 10.1016/j.ijbiomac.2020.01.108
PMID: 31935412
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We report a novel class of chitosan (CS)-based hybrid semi-interpenetrating nanogel catalyst by the reductant-free green synthesis of gold nanoparticles (Au NPs) within the CS-poly(methacrylic acid) ([email protected]) polymer network. The covalently cross-linked [email protected] nanogel with CS chains semi-interpenetrating (semi-IPN) in the PMAA cross-linked network show superior colloidal stability and improved catalytic activity. The synthesized [email protected] semi-IPN nanogel was applied as a superior modifier to create a new and sorely selective electrochemical sensing platform for the determination of antileukemic drug 5-fluorouracil (5-FU). The existence of -OH and -COOH groups in the CS and PMAA offers numerous binding sites for 5-FU. This assures the incorporation of Au NPs which affords a larger surface area and ameliorate electrical conductivity. Besides, the synergic effect amid both compounds improves the detection of 5-FU. Under optimal conditions, the constructed sensor offered a good performance in determination of 5-FU with a wide linear range from 0.1-497 μM and low detection limits of 0.03 μM, respectively. Further, this study proved that the fabricated sensor could be useful for analysis of 5-FU in actual human blood serum samples. Copyright © 2020. Published by Elsevier B.V.

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