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New prospects for research on cephalosporins.

Authors
  • Neuman, N
Type
Published Article
Journal
Drugs under experimental and clinical research
Publication Date
Jan 01, 1985
Volume
11
Issue
7
Pages
421–426
Identifiers
PMID: 3836864
Source
Medline
License
Unknown

Abstract

The present paper reviews the newly-developed cephalosporins and considers their potential for filling the gaps left by earlier cephalosporins in terms of of spectrum of activity, pharmacokinetic parameters, development of resistance and tolerability. Research on narrow-spectrum cephalosporins, directed specifically against enterobacteria and Pseudomonas, on cephalosporins with a low inoculum effect and on oral cephalosporins is discussed. The chemical substitutions responsible for enhancing or reducing the activity of cephalosporins against various bacteria, for altering pharmacokinetic behaviour and for producing unwanted side-effects are described.

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