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New phenylpropanoids and in vitro α-glucosidase inhibitors from Balanophora japonica.

Authors
  • Zhou, Tong
  • Zhang, Xiao-hui
  • Zhang, Shu-wei
  • Liu, Shan-shan
  • Xuan, Li-jiang
Type
Published Article
Journal
Planta Medica
Publisher
Georg Thieme Verlag KG
Publication Date
Mar 01, 2011
Volume
77
Issue
5
Pages
477–481
Identifiers
DOI: 10.1055/s-0030-1250464
PMID: 20979022
Source
Medline
License
Unknown

Abstract

Five new phenylpropanoids, named balajaponins A-E (1-5), were isolated from Balanophora japonica, along with 24 known compounds. Among them, three hydrolysable tannins (6-8) showed specific in vitro α-glucosidase inhibition, with IC₅₀ values in the range of 1-4 µM. Kinetic analysis revealed that they all acted in a noncompetitive mode.

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