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New and Old Osteocytic Cell Lines and 3D Models.

Authors
  • Divieti Pajevic, Paola1
  • 1 Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, 700 Albany Street, W201E, Boston, MA, 02118, USA. [email protected]
Type
Published Article
Journal
Current osteoporosis reports
Publication Date
Oct 01, 2020
Volume
18
Issue
5
Pages
551–558
Identifiers
DOI: 10.1007/s11914-020-00613-3
PMID: 32794140
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells, RECENT FINDINGS: Osteocytes are the main orchestrators of bone remodeling. They control both osteoblasts and osteoclast activities via cell-to cell communication or through secreted factors. Osteocytes are also the mechanosensors of the bone and they orchestrate skeletal adaptation to loads. Recent discoveries have greatly expanded our knowledge and understanding of these cells and new models are now available to further uncover the functions of osteocytes. Novel osteocytic cell lines, primary cultures, and 3D scaffolds are now available to investigators to further unravel the functions and roles of these cells.

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