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New N-terminal protecting group for peptide attachment to insoluble supports.

Authors
  • Bentley, KW
Publication Date
Dec 01, 1978
Source
ANSTO Publications Online
Keywords
License
Unknown
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Abstract

Cobalt(III) active ester complexes [Co(en)2(NH2CHRCOOR')]-(CIOO3, where en is ethylenediamine, R is H or -CH2- and R1 is CH3, C2H5 or C3H7 , have been used to provide N-terminal protection before the attachment of peptides to insoluble polymeric supports. The protecting group can be removed readily and quantitatively using normal physiological parameters from peptides attached to non-crosslinked resins.

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