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A new monoterpenoid glycoside from Myrica esculenta and the inhibition of angiotensin I-converting enzyme.

Authors
  • Nguyen, Xuan Nhiem
  • Phan, Van Kiem
  • Chau, Van Minh
  • Bui, Huu Tai
  • Nguyen, Xuan Cuong
  • Vu, Kim Thu
  • Hoang, Le Tuan Anh
  • Jo, Sung-Hoon
  • Jang, Hae-Dong
  • Kwon, Young-In
  • Kim, Young Ho
Type
Published Article
Journal
Chemical and Pharmaceutical Bulletin
Publisher
Pharmaceutical Society of Japan
Publication Date
September 2010
Volume
58
Issue
10
Pages
1408–1410
Identifiers
PMID: 20930414
Source
Medline
License
Unknown

Abstract

One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 µM, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07-1.41% at concentration of 100 µM.

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