New minimum length requirement for a T cell epitope for experimental allergic neuritis.
Immune Response Corporation, San Diego, CA 92121.
- Published Article
Journal of Neuroimmunology
- Publication Date
May 01, 1990
The bovine P2 protein induces experimental allergic neuritis (EAN) in Lewis rats. Using synthetic peptides representing regions of the P2 protein sequence and P2-specific neuritogenic T cell lines, we have demonstrated that the minimum peptide length requirement for the T cell epitope for EAN is residues 61-70 of the P2 protein having the sequence EISFKLGQEF. Adding a threonine at the NH2 terminus of this peptide reproduces residues 60-70 of the P2 protein sequence and significantly enhances the neuritogenic capability of this peptide.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1692033