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New minimum length requirement for a T cell epitope for experimental allergic neuritis.

Authors
  • Olee, T1
  • Powell, H C
  • Brostoff, S W
  • 1 Immune Response Corporation, San Diego, CA 92121.
Type
Published Article
Journal
Journal of Neuroimmunology
Publisher
Elsevier
Publication Date
May 01, 1990
Volume
27
Issue
2-3
Pages
187–190
Identifiers
PMID: 1692033
Source
Medline
License
Unknown

Abstract

The bovine P2 protein induces experimental allergic neuritis (EAN) in Lewis rats. Using synthetic peptides representing regions of the P2 protein sequence and P2-specific neuritogenic T cell lines, we have demonstrated that the minimum peptide length requirement for the T cell epitope for EAN is residues 61-70 of the P2 protein having the sequence EISFKLGQEF. Adding a threonine at the NH2 terminus of this peptide reproduces residues 60-70 of the P2 protein sequence and significantly enhances the neuritogenic capability of this peptide.

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