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A new microcystin producing Nostoc strain discovered in broad toxicological screening of non-planktic Nostocaceae (cyanobacteria).

Authors
  • Kust, Andreja1
  • Urajová, Petra2
  • Hrouzek, Pavel3
  • Vu, Dai Long2
  • Čapková, Kateřina4
  • Štenclová, Lenka5
  • Řeháková, Klára4
  • Kozlíková-Zapomělová, Eliška4
  • Lepšová-Skácelová, Olga6
  • Lukešová, Alena7
  • Mareš, Jan8
  • 1 The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic; Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic. , (Czechia)
  • 2 Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic. , (Czechia)
  • 3 Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic. , (Czechia)
  • 4 The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic. , (Czechia)
  • 5 The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic. , (Czechia)
  • 6 Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic. , (Czechia)
  • 7 Institute of Soil Biology, The Czech Academy of Sciences, Biology Centre, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic. , (Czechia)
  • 8 The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic; Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic. Electronic address: [email protected] , (Czechia)
Type
Published Article
Journal
Toxicon : official journal of the International Society on Toxinology
Publication Date
May 21, 2018
Volume
150
Pages
66–73
Identifiers
DOI: 10.1016/j.toxicon.2018.05.007
PMID: 29772212
Source
Medline
Keywords
License
Unknown

Abstract

Benthic cyanobacteria recognized as producers of natural products, including cyanotoxins, have been neglected for systematic toxicological studies. Thus, we have performed a broad study investigating cyanotoxin potential of 311 non-planktic nostocacean representatives combining molecular and chemical analyses. Out of these, a single strain Nostoc sp. Treb K1/5, was identified as a new microcystin producer. Microcystins [Asp3]MC-YR, [Asp3]MC-FR, [Asp3]MC-HtyR and Ala-Leu/Ile-Asp-Arg-Adda-Glu-Mdha are reported for the first time from the genus Nostoc. All the studied strains were also analyzed for the occurrence of nodularins, cylindrospermopsin and (homo)anatoxin-a, yet no novel producer has been discovered. Our findings indicate rare occurrence of the common cyanotoxins in non-planktic nostocaceae which is in contrast with frequent reports of cyanotoxin producers among phylogenetically closely related planktic cyanobacteria.

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