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New insights into osteoarthritis: early developmental features of an ageing-related disease.

Authors
Type
Published Article
Journal
Current Opinion in Rheumatology
1040-8711
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
20
Issue
5
Pages
553–559
Identifiers
DOI: 10.1097/BOR.0b013e32830aba48
PMID: 18698177
Source
Medline
License
Unknown

Abstract

We hypothesize that these osteoarthritis susceptibility genes may play a dual negative role. In early developmental processes, they may involve aberrant skeletal morphogenesis leading to either malformation of joints or aberrant bone composition or both, thereby increasing the biomechanical burden on the articular cartilage surface. Later in life in articular cartilage, these genes may affect the propensity of articular chondrocytes to become hypertrophic. As hypertrophic chondrocytes are not able to maintain cartilage homeostasis, these genes may, in part, be responsible for both the onset of osteoarthritis and the progression towards clinical outcomes. Major therapeutic advances may come from a focus on factors that enhance phenotypic stability of the articular chondrocyte during life, promoting the healthy articular cartilage.

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