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New insights into cohesin loading.

Authors
  • Litwin, Ireneusz1
  • Wysocki, Robert2
  • 1 Institute of Experimental Biology, University of Wroclaw, 50-328, Wroclaw, Poland. [email protected] , (Poland)
  • 2 Institute of Experimental Biology, University of Wroclaw, 50-328, Wroclaw, Poland. , (Poland)
Type
Published Article
Journal
Current Genetics
Publisher
Springer-Verlag
Publication Date
Jun 19, 2017
Identifiers
DOI: 10.1007/s00294-017-0723-6
PMID: 28631016
Source
Medline
Keywords
License
Unknown

Abstract

Cohesin is a conserved, ring-shaped protein complex that encircles sister chromatids and ensures correct chromosome segregation during mitosis and meiosis. It also plays a crucial role in the regulation of gene expression, DNA condensation, and DNA repair through both non-homologous end joining and homologous recombination. Cohesins are spatiotemporally regulated by the Scc2-Scc4 complex which facilitates cohesin loading onto chromatin at specific chromosomal sites. Over the last few years, much attention has been paid to cohesin and cohesin loader as it became clear that even minor disruptions of these complexes may lead to developmental disorders and cancers. Here we summarize recent developments in the structure of Scc2-Scc4 complex, cohesin loading process, and mediators that determine the Scc2-Scc4 binding patterns to chromatin.

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