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A New Individually Addressable Micro-LED Array for Photogenetic Neural Stimulation.

Authors
  • McGovern, B
  • Berlinguer Palmini, R
  • Grossman, N
  • Drakakis, E
  • Poher, V
  • Neil, M A A
  • Degenaar, P
Type
Published Article
Journal
IEEE transactions on biomedical circuits and systems
Publication Date
Dec 01, 2010
Volume
4
Issue
6
Pages
469–476
Identifiers
DOI: 10.1109/TBCAS.2010.2081988
PMID: 23853385
Source
Medline
Language
English
License
Unknown

Abstract

Here, we demonstrate the use of a micro light emitting diode (LED) array as a powerful tool for complex spatiotemporal control of photosensitized neurons. The array can generate arbitrary, 2-D, excitation patterns with millisecond and micrometer resolution. In particular, we describe an active matrix control address system to allow simultaneous control of 256 individual micro LEDs. We present the system optically integrated into a microscope environment and patch clamp electrophysiology. The results show that the emitters have sufficient radiance at the required wavelength to stimulate neurons expressing channelrhodopsin-2 (ChR2).

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