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New indicators for systematic assessment of aortic morphology: a narrative review

Authors
  • Luan, Jingyang1
  • Mao, Le1
  • Zhu, Ziqing2
  • Fu, Weiguo1
  • Zhu, Ting1
  • 1 Fudan University, Shanghai , (China)
  • 2 Southern Medical University, Guangzhou , (China)
Type
Published Article
Journal
Journal of Thoracic Disease
Publisher
AME Publishing Company
Publication Date
Jan 01, 2021
Volume
13
Issue
1
Pages
372–383
Identifiers
DOI: 10.21037/jtd-20-2728
PMID: 33569218
PMCID: PMC7867839
Source
PubMed Central
Keywords
Disciplines
  • Review Article
License
Unknown

Abstract

In order to prevent the occurrence of aortic adverse events in ascending thoracic aortic aneurysm patients, preventive surgery is the sole option in case of large aneurysm. Identifying high-risk patients timely and accurately requires effective predictive indicators of aortic adverse events and accurate risk stratification thresholds. Absolute diameter measured after a single imaging examination, which has been used as the predictive indicator for decades, has been proved to be ineffective for risk stratification in moderately dilated aorta. Previously, new indicators combining absolute diameters with personalized parameters have been reported to show better predictive power of aortic adverse events than absolute diameters by correcting the effect of these parameters on the diameters. Meanwhile, combining three-dimensional parameters to formulate risk stratification thresholds not only may characterize the aortic risk morphology more precisely, but also predict aortic adverse events more accurately. These new indicators may provide more systematic assessment methods of patients’ risk, formulate more personalized intervention strategies for ascending thoracic aortic aneurysm patients, and also provide a basis for researchers to develop more accurate and effective risk thresholds. We also highlight that the algorithm obtained by combining multiple indicators may be a better choice compared with single indicator, but this still requires the support of more evidence. Due to the particularity of syndromic aortic disease, whether these new indicators can be used for its risk stratification is still uncertain. Therefore, the scope of this manuscript does not include this kind of disease.

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