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New immortalized cell lines of patients with small supernumerary marker chromosome: towards the establishment of a cell bank.

Authors
  • Tönnies, Holger
  • Pietrzak, Joanna
  • Bocian, Ewa
  • MacDermont, Kay
  • Kuechler, Alma
  • Belitz, Britta
  • Trautmann, Udo
  • Schmidt, Angela
  • Schulze, Berndt
  • Rodríguez, Laura
  • Binkert, Franz
  • Yardin, Catharine
  • Kosyakova, Nadezda
  • Volleth, Marianne
  • Mkrtchyan, Hasmik
  • Schreyer, Isolde
  • von Eggeling, Ferdinand
  • Weise, Anja
  • Mrasek, Kristin
  • Liehr, Thomas
Type
Published Article
Journal
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Publication Date
Jun 01, 2007
Volume
55
Issue
6
Pages
651–660
Identifiers
PMID: 17341473
Source
Medline
License
Unknown

Abstract

Sixteen newly established cell lines with small supernumerary marker chromosomes (sSMC) derived from chromosomes 1, 2, 4, 6, 7, 8, 14, 15, 16, 18, 19, 21, and 22 are reported. Two sSMC are neocentric and derived from 15q24.1-qter and 2q35-q36, respectively. Two further cases each present with two sSMC of different chromosomal origin. sSMC were characterized by multicolor fluorescence in situ hybridization for their chromosomal origin and genetic content. Moreover, uniparental disomy of the sister chromosomes of the sSMC was excluded in all nine cases studied for that reason. The 16 cases provide information to establish a refined genotype-phenotype correlation of sSMC and are available for future studies.

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