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New G-Quadruplex-Forming Oligodeoxynucleotides Incorporating a Bifunctional Double-Ended Linker (DEL): Effects of DEL Size and ODNs Orientation on the Topology, Stability, and Molecularity of DEL-G-Quadruplexes

Authors
  • marzano, maria
  • falanga, andrea patrizia
  • d’errico, stefano
  • pinto, brunella
  • roviello, giovanni nicola
  • piccialli, gennaro
  • oliviero, giorgia
  • borbone, nicola
Publication Date
Feb 12, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

SEC), circular dichroism (CD), and NMR studies in comparison with the previously reported monomeric tetra-ended-linker (TEL) analogues and with the corresponding tetramolecular species (TG4T)4. The structural characterization of DEL-ODNs confirmed the formation of stable, bimolecular DEL-G4s for all DEL-ODNs, as well as of additional DEL-G4 multimers with higher molecular weights, thus suggesting a way towards the obtainment of thermally stable DNA nanostructures based on reticulated DEL-G4s.

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