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The New Generation Immunochemical Test for Fecal Occult Blood (ColonView Quick Test) Shows a High Diagnostic Accuracy in Colorectal Cancer Detection.

Authors
  • Meklin, Jannica1
  • Eskelinen, Maaret1
  • Guimaraes, Denise Peixoto2
  • Selander, Tuomas3
  • Inkinen, Jenni4
  • Tiusanen, Tapani4
  • Syrjänen, Kari2, 5
  • Eskelinen, Matti6
  • 1 Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland. , (Finland)
  • 2 Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil. , (Brazil)
  • 3 Science Service Center, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland. , (Finland)
  • 4 Department of Clinical Research, Biohit Oyj, Helsinki, Finland. , (Finland)
  • 5 SMW Consultants, Ltd., Kaarina, Finland. , (Finland)
  • 6 Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland; [email protected] , (Finland)
Type
Published Article
Journal
Anticancer Research
Publisher
International Institute of Anticancer Research
Publication Date
Oct 01, 2021
Volume
41
Issue
10
Pages
5071–5079
Identifiers
DOI: 10.21873/anticanres.15323
PMID: 34593457
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The present study compared the accuracy of visually analyzed (VA) and automatically analyzed (AA) ColonView (CV) quick test; a new-generation immunochemical test (FIT) for Hb and Hb/Hp (Biohit Oyj, Helsinki, Finland) in subjects participating in colorectal cancer (CRC) detection in Brazil. A traditional gFOBT test (HemoccultSENSA) was used as a reference. A cohort of 368 colonoscopy-referral patients were asked to collect 3 consecutive fecal samples, to be analysed by both assays (CV, SENSA). In receiver operating characteristic (ROC) analysis for the AA reading, the optimal cut-off value for CV Hb AA (test AA 3) was ≥117 and that for CV Hb/Hp AA (test AA 4) was ≥48. In the hierarchical summary receiver operating characteristic (HSROC) analysis for pooled accuracy of CV with AA and VA reading, the AUC values for i) VA and ii) AA were as follows: i) AUC=0.859 (95%CI=0.839-0.879), ii) AUC=0.931 (95%CI=0.920-0.942). The difference between these AUC values (Roccomp analysis) was statistically significant (p=0.0024). The present study confirms the previous studies on the applicability of the ColonView quick test (a new-generation FIT) in CRC screening. Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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