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A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage.

Authors
  • Prunell, Giselle F
  • Mathiesen, Tiit
  • Svendgaard, Niels-Aage
Type
Published Article
Journal
Neuroreport
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 20, 2002
Volume
13
Issue
18
Pages
2553–2556
Identifiers
PMID: 12499866
Source
Medline
License
Unknown

Abstract

A new experimental model of subarachnoid hemorrhage (SAH) in rats is described. A needle was stereotaxically placed in the prechiasmatic cistern and 300, 250 or 200 microl of blood was injected manually, keeping the intracranial pressure (ICP) at the mean arterial blood pressure (MABP) level. An acceptable mortality was observed only after injection of 200 microl of blood. In this group, MABP and ICP increased immediately after SAH, but soon approached baseline levels. The subarachnoid blood was mainly distributed in the basal cisternal system and its estimated volume was about 95% of the amount injected. This new model resembles clinical SAH, is very reproducible, easy to use and seems to be a suitable model for studies of the pathophysiology of SAH.

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