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A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Authors
  • Van Do, Truong Nhat1, 2
  • Nguyen, Hai Xuan1, 2
  • Le, Tho Huu1, 2
  • Dang, Phu Hoang1, 2
  • Nguyen, Mai Thanh1, 2
  • Thi Nguyen, Mai Thanh1, 3, 2
  • Nguyen, Nhan Trung1, 3, 2
  • 1 Faculty of Chemistry, University of Science, Vietnam , (Vietnam)
  • 2 Vietnam National University, Vietnam , (Vietnam)
  • 3 Cancer Research Laboratory, University of Science, Vietnam , (Vietnam)
Type
Published Article
Journal
Zeitschrift für Naturforschung C
Publisher
Walter de Gruyter GmbH
Publication Date
Nov 18, 2021
Volume
77
Issue
5-6
Pages
219–223
Identifiers
DOI: 10.1515/znc-2021-0096
Source
De Gruyter
Keywords
License
Yellow

Abstract

A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2–5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).

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