A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Truong Nhat Van Do; Hai Xuan Nguyen; Tho Huu Le; Phu Hoang Dang; Mai Thanh Nguyen; Mai Thanh Thi Nguyen; Nhan Trung Nguyen

doi:10.1515/znc-2021-0096

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A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Authors

Van Do, Truong Nhat^{1, 2}
Nguyen, Hai Xuan^{1, 2}
Le, Tho Huu^{1, 2}
Dang, Phu Hoang^{1, 2}
Nguyen, Mai Thanh^{1, 2}
Thi Nguyen, Mai Thanh^{1, 3, 2}
Nguyen, Nhan Trung^{1, 3, 2}

¹ Faculty of Chemistry, University of Science, Vietnam , (Vietnam)
² Vietnam National University, Vietnam , (Vietnam)
³ Cancer Research Laboratory, University of Science, Vietnam , (Vietnam)

Type

Published Article

Journal

Zeitschrift für Naturforschung C

Publisher

Walter de Gruyter GmbH

Publication Date

Nov 18, 2021

Volume

77

Issue

5-6

Pages

219–223

Identifiers

DOI: 10.1515/znc-2021-0096

Source

De Gruyter

Keywords

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Abstract

A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2–5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).

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Abstract

A new diphenylheptanoid from the rhizomes of Curcuma zedoaria.

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