Affordable Access

deepdyve-link deepdyve-link
Publisher Website

New development in the diagnosis of dengue infections.

Authors
  • 1
  • 1 University Malaya, Faculty of Medicine, Department of Medical Microbiology, Kuala Lumpur, Malaysia. , (Malaysia)
Type
Published Article
Journal
Expert opinion on medical diagnostics
1753-0067
Publication Date
Volume
7
Issue
1
Pages
99–112
Identifiers
DOI: 10.1517/17530059.2012.718759
PMID: 23530846
Source
Medline
License
Unknown

Abstract

To diagnose dengue, an understanding of the complex immune responses and the clinical features of this disease is essential. The MAC-ELISA currently remains the assay of choice but needs further evaluation and confirmation. Viral RT-PCR and NS1 have gained interest but their inconsistencies and great variability are of concern. Combinations of these tests have improved sensitivity but specificity issues still exist. Consequently, the favorable method of diagnosing dengue currently is to run multiple tests or obtain a paired sample so that more than one parameter is detected or a rising titer is demonstrated.

Statistics

Seen <100 times