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New cytotoxic triterpene glycoside from the East China Sea cucumber Holothuria nobilis.

Authors
  • Zhang, Jia-Jia
  • Zhu, Qi-Ke
  • Wu, Jun
  • Zhang, Hui-Wen
Type
Published Article
Journal
Natural product communications
Publication Date
Feb 01, 2015
Volume
10
Issue
2
Pages
247–248
Identifiers
PMID: 25920252
Source
Medline
License
Unknown

Abstract

A new cytotoxic triterpene glycoside named nobiliside E (1) has been obtained from the East China Sea cucumber Holothuria nobilis Selenka. Its structure was determined on the basis of NMR spectroscopic and MS analyses, together with chemical evidence. The new compound showed significant cytotoxicity to eight human tumor cell lines with IC50 values in the range of 0.53-4.06 μg/mL.

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