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New butyrolactone and other metabolites from the bark of Endlicheria arenosa against of the phytopathogen Colletotrichum tamarilloi.

Authors
  • Albarracín, Lady T1
  • Delgado, Wilman1
  • Cuca, Luis Enrique1
  • Ávila, Mónica C1
  • 1 a Research group: Estudio químico y de actividad biológica de Rutaceae y Myristicaceae Colombianas, Science Faculty, Chemistry Department , Universidad Nacional de Colombia , Bogotá , Colombia. , (Colombia)
Type
Published Article
Journal
Natural product research
Publication Date
Mar 01, 2019
Volume
33
Issue
5
Pages
687–694
Identifiers
DOI: 10.1080/14786419.2017.1408090
PMID: 29191041
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In this work, screening of Lauraceae species for their antifungal activity against Collectotrichum tamarilloi was carried out and the ethanol extract derived from the bark of Endlicheria arenosa was found to be the best candidate. From the ethanolic extract of the bark of E. arenosa, the hexane and chloroform fractions were found to be active, from these five fatty acids were identified and two lactones were isolated. The most active fatty acid was the dodecanoic acid with a minimal inhibitory concentration (MIC) of 78.0 μM. The butyrolactone 3R,4R-licunolide A, it has not previously reported, and licunolide B show both the lowest MIC (55.3 μM). This is the first report of compounds of natural origin as growth inhibitors of C. tamarilloi.

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