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New branched amino acids for high affinity dendrimeric DC-SIGN ligands

Authors
  • Cattiaux, Laurent
  • Porkolab, Vanessa
  • Fieschi, Franck
  • Mallet, Jean-Maurice
Publication Date
Mar 01, 2018
Source
HAL-UPMC
Keywords
Language
English
License
Unknown
External links

Abstract

A branched amino acid was synthesized from methyl glucopyranoside; this amino acid presents three amino groups protected by Fmoc and one acid group and can be used in classic peptide synthesis. In parallel, similar azido terminated blocks were synthesized. Successive coupling reaction and deprotection afforded dendrimers with up to 27 azido functional groups. As an example of application, d-mannose and l-fucose residues were linked through CuAAC coupling and resulting glycodendrimers were evaluated in their interaction with DC-SIGN using SPR competition assay.

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