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New biologically active triterpene-saponins from Randia dumetorum.

Authors
  • Dubois, M A
  • Benze, S
  • Wagner, H
Type
Published Article
Journal
Planta medica
Publication Date
Oct 01, 1990
Volume
56
Issue
5
Pages
451–455
Identifiers
PMID: 2077549
Source
Medline
License
Unknown

Abstract

Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-( beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities.

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